Product Description
Item Name: Ampicillin Sodium
CAS NO.: 69-52-3
Molecular Formula:C16H18N3NaO4S
EINECS:
Item Description
Item nanme: Ampicillin Sodium
Item character: This product is white.
Indication:
1. As an alternative drug for penicillin allergy patients to treat the following infections: acute tonsillitis, acute pharyngitis and sinusitis caused by hemolytic streptococcus and Streptococcus pneumoniae; scarlet fever and cellulitis caused by hemolytic streptococcus; diphtheria and diphtheria carriers; gas gangrene, anthrax, tetanus; actinomycosis; syphilis; listeriosis, etc.
2. Legionellosis.
3. Mycoplasma pneumoniae pneumonia.
4. Chlamydia pneumoniae pneumonia.
5. Other urogenital infections caused by Chlamydia and mycoplasma.
6. Chlamydia trachomatis conjunctivitis.
7. Oral infection caused by anaerobic bacteria.
8. Campylobacter jejuni enteritis.
9. Pertussis.
10. Recurrence of rheumatic fever, infective endocarditis (rheumatic heart disease, congenital heart disease, after heart valve replacement), prevention of oral or upper respiratory tract infection (penicillin replacement).
Item specifications:125g (125000 units) according to erythromycin
Usage and dosage: 75-2g per day for adults and 20-30mg / kg for children.
In the treatment of legionellosis, adults were given 0.5-1.0 g once a day, 4 times a day.
25g, twice a day.
When used as prophylactic drug for infective endocarditis, 1g was taken orally 1 hour before operation, and 0.5g was taken again 6 hours after operation.
Adverse reactions
1. After taking this product, hepatotoxicity is more common than other erythromycin preparations. After taking this product for several days or 1-2 weeks, patients may have fatigue, nausea, vomiting, abdominal pain, rash, fever, etc. Sometimes jaundice, liver function test showed cholestasis, often recovered after withdrawal.
2. Gastrointestinal reactions include diarrhea, nausea, vomiting, upper and middle abdominal pain, tongue and mouth pain, hypogastria, etc.
3. High dose (≥ 4G / day) application, especially in patients with liver and kidney diseases or elderly patients, may cause hearing loss, which is mainly related to high blood concentration (] 12mg / L), and most of them can recover after drug withdrawal.
4. Allergic reactions were drug fever, rash, eosinophilia, etc. The incidence was about 0.5% - 1%.
5. Others: occasional arrhythmia, oral or vaginal Candida infection.
Taboo:
It is forbidden for those allergic to erythromycin.
Matters needing attention:
1. It is more common that alt, AST, AKP and bilirubin increase after taking this product than other erythromycin preparations.
2. The treatment of hemolytic streptococcus infection should last at least 10 days to prevent the occurrence of acute rheumatic fever.
3. Patients with renal dysfunction generally do not need to reduce the dosage.
When the patient is allergic or can not tolerate one of erythromycin.
5. It should be used with caution in patients with chronic liver disease and liver function damage.
6. The sensitivity of different bacteria to erythromycin is different, so the drug sensitivity test should be done.
7. Interference to diagnosis: erythromycin can interfere with the fluorescence determination of higerty method, and make the determination value of urinary catecholamine pseudo increase. The serum alkaline phosphatase, bilirubin, alanine aminotransferase and aspartate aminotransferase may be increased.
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